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The wood structures and fabrication methods are illustrated in Fig
They recruit and activate innate immune cells (such as macrophages) and promote local inflammation and tissue damage
For instance, researchers conducted a detailed proteomic analysis of Kaiyu Zhishen Decoction and identified its key active componentsprimarily flavonoids and phenolic acidsas major contributors to its antidepressant effects
While proof-of-concept is firmly established in rodent models, issues such as delivery efficiency, long-term integration, and avoidance of maladaptive circuitry must be resolved to enable therapeutic implementation in the human CNS
References Gul, N
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