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Kolarikova M, Hosikova B, Dilenko H, BartonTomankova K, Valkova L, Bajgar R, et al

Acknowledgements Cristian-Daniel Llach received the support of a fellowship from la Caixa Foundation (ID 100010434 - fellowship code LCF/BQ/EU22/11930062)

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Pathogenesis of systemic lupus erythematosus: risks, mechanisms and therapeutic targets

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Studies show that supplemental melatonin changes the composition of the gut microbiome, reduces weight, decreases fatty liver, and decreases low-grade inflammation.[ref] Another animal study showed that melatonin not only changes the gut microbiome but also improves the intestinal barrier and increases gastrointestinal motility.[ref] Viral and parasitic infections: Cardiomyopathy, caused by a viral infection (Coxsackievirus B3), is prevented by supplemental melatonin.[ref] Quite a few parasitic infections show improvement with melatonin including malaria, toxoplasmosis, and trypanosomiasis.[ref] Pretreatment with melatonin decreases the damage to the lungs in RSV infection.[ref] Melatonin may even help with the Ebola virus.[ref] Migraines: A randomized placebo-controlled trial showed that melatonin (3mg/night) for 12 weeks was superior to placebo for migraine prevention