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68 In non-transformed cells, NRF2 promotes the entry of cysteine into the taurine synthesis pathway via CDO1, 69 and modestly limits the accumulation of cysteine and glutathione synthesis
RQC factors Components of the ribosome-associated quality control pathway that detect stalled or collided ribosomes and mediate the ubiquitination, extraction or degradation of incomplete nascent chains after the dissociation of ribosomes
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Vitamin C helps "recharge" glutathione after it has neutralized a free radical, turning it back into its active state
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Predominantly, these studies have been conducted in chondrocyte cells rather than synovial fibroblasts
