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Identify and treat underlying cause: Infection

Lundstrm et al., 2011

When the skin is infected or stimulated by ultraviolet radiation, NOX activity increases significantly, producing large amounts of superoxide anion (O 2 ) in the skin, which induces high cytotoxicity (Figure 1) (Nakai and Tsuruta, 2021)

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Signaling pathways in melanosome biogenesis and pathology.The International Journal of Biochemistry & Cell Biology

Ruan, H