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The concern is theoretical but not dismissible over multi-year use

Rotate between the left and right sides of your abdomen, thighs, and upper arms on a consistent schedule

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The in vivo HITI-mediated knock-in efficiency at the Alb locus in this study is comparable to that of other knock-in methods, such as HDR (~2%) and NHEJ (~2%) 33,34

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Several alternative therapeutic strategies have been investigated, including protein kinase C inhibitors [10], darbepoetin alfa [11], endothelin receptor antagonists (ERAs) [12], direct renin inhibitors [13], nuclear factor erythroid 2-related factor 2 activators [14], and combination of ACE inhibitor and ARB [15]