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These include significant reductions in HbA1c (a key measure of long-term blood sugar control), substantial weight loss, improved Time in Range (TIR) and Time in Tight Target Range (TITR) on continuous glucose monitors, and a decrease in the total daily insulin dose required
Its clinical manifestations include motor symptoms, such as bradykinesia, resting tremor, myotonia, and postural balance disorders, and non-motor symptoms, such as hyposmia, sleep disturbance, constipation, and mental and cognitive impairment (1)
In the STEP 1 trial extension, people who stopped semaglutide regained about two-thirds of their lost weight within a year
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Tirzepatide works in a different way than semaglutide