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Studies of HFrEF patients raised questions about the safety profile of GLP-1RA therapy in this subpopulation

These same molecules were also subsequently approved for weight lossliraglutide in 2014, and semaglutide, as Wegovy, in 2021

This shortage opened a temporary but lucrative opportunity for compounding pharmacies, which the Federal Food, Drug, and Cosmetic Act permits to produce copycat versions of branded drugs during officially declared shortages

Over-the-counter remedies such as simeticone (for gas and bloating) or loperamide (for diarrhoea) can provide symptomatic relief, though patients should consult their GP or pharmacist before regular use

In the Phase 2 trial, 100% of participants on 8mg or 12mg achieved at least 5% weight loss (the threshold for health benefits)

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