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Patients should also make necessary lifestyle changes, such as regular exercise and a reduced-calorie diet
These include leptin sensitizers, Y2R agonists (Eli Lilly, Novo Nordisk), amylin/calcitonin dual agonists (Nordic Biosciences, Amylin Pharmaceuticals), and ghrelin-targeting agents (Noxxon, Cytos) Novel mechanisms : There are several companies taking differentiated (non-incretin) approaches to obesity
Women who become pregnant whilst in a clinical trial should stop treatment immediately and inform their trial team
10.1016/j.diabres.2014.06.010 110
Our network meta-analysis has certain limitations
Real needle-free options exist: the Wegovy oral tablet (FDA-approved December 2025) and experimental microneedle patches in early clinical trials
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