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CrossRef Steatotic liver disease and cancer: from pathogenesis to therapeutic targets Zhihong Yang, Zhenjie Liu, Wanqing Liu, Xiaocheng Charlie Dong eGastroenterology .2025

To address this treatment gap, we engineered a proprotein convertase subtilisin/kexin type 9 (PCSK9) neutralizing monoclonal antibody (mAb) fused to a glucagon-like peptide-1 (GLP-1) receptor (GLP-1R) agonist peptide to deliver low-density lipoprotein cholesterol (LDL-C) lowering capabilities combined with glycaemic and weight control in a single molecule

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The constructs were cloned into both pcDNA3.1 and pFastBac vectors for functional assays in mammalian cells and protein expression in insect cells, respectively

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