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2020 Gorgojo-Martnez, J
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(2) molecular dynamics simulated annealing restraining FOXO4 FH (without flexible regions) harmonically to its template structure (using a non-crystallographic force constant of 10,000 kcal mol 1 2 ), with additional dihedral angle restraints from 1 H, 15 N, and 13 C chemical shifts using TALOS-N 56 , hydrogen bond restraints (region p53 residues 48-55
Based on early-phase pharmacokinetic data, retatrutide has an estimated half-life of approximately six days, supporting once-weekly dosing
Both drugs also carry a black box warning that they may increase the risk of thyroid C-cell tumors
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