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Due to the uncertainty regarding the optimum balance of GLP-1R and GCGR agonism in a unimolecular co-agonist, development of novel peptides varied from sequence modification and enhancing stability of native OXM, sequence modification of the glucagon peptide to confer increased GLP-1R potency or modification of GLP-1 peptide to confer increased GCGR potency

Overexpression of IGF-1 in muscles causes an increase in muscle size

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A 40mg pen typically lasts around 8 weeks on a moderate weekly schedule