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Activation of the antioxidant enzyme 1-CYS peroxiredoxin requires glutathionylation mediated by heterodimerization with pi GST
Cleary, D.B., et al
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For example, reduced EAAT2 activity leads to elevated extracellular glutamate concentrations [309, 310], which trigger excessive calcium influx into both neurons and astrocytes
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FDAs July 2026 briefing document states that the agency did not intend to issue a final determination until it considered committee input and completed its reviews
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