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Clinical Evidence for Weight Loss and Metabolic Health A Phase 2 trial published in NEJM (2023) reported approximately 24.2% mean body weight reduction over 48 weeks at the highest dose, alongside improvements in fasting glucose, insulin sensitivity, triglycerides, and waist circumference
A long-time collaborator with Dr
The result: a medication built on the same active pharmaceutical ingredient - semaglutide - but operating in a completely different regulatory category
This includes the lowest dose evaluated, 2.5 mg weekly, for which 98% of the initial weight loss was maintained four weeks after the last dose was administered
Stimulating these pathways may indirectly affect reward processing and motivation, pathways that also matter in ADHD
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