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Novo in December 2025 nevertheless pushed through with an FDA filing for CagriSema as a weight-loss medicine, proposing weekly use in patients with obesity or who are overweight with at least one related comorbidity
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It also appears in peripheral organs and body fluids, suggesting systemic regulatory functions beyond the central nervous system
Exogenous MOTS-c supplementation may partially restore this responsiveness
Proof for this effect in human beings is, however, wanting, and therefore more evidence would be needed
[ 4 ] However, enthusiasm surrounding DSIP was shaken due to difficulties replicating the original findings
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