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Without uridine, the cell compensates for pyrimidine shortage by over-activating ATP-consuming salvage pathways (UCK2, TK1, dCK), which potentially drives mitochondrial biogenesis to generate more ATP for these phosphorylation reactions 63

Phase 2 trials used a structured titration protocol, typically starting at 0.5 mg once weekly and escalating to maintenance doses of up to 12 mg once weekly

Histological examination showed perivascular superficial and dermal chronic inflammatory cell infiltration associated with eosinophils and minimal spongiotic changes, and a direct immunofluorescence test was negative

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The lateral meniscus, along the outer portion of the knee, bears up to 80% of the stress load exerted on the lateral compartment of the knee