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They affect dopamine release, which is your brains way of saying this feels good. When you take a GLP-1, those reward pathways get dialed down
Tirzepatide: Another Relevant Comparison Tirzepatide (Mounjaro/Zepbound), a dual GIP/GLP-1 agonist approved by the FDA, provides another useful reference point
Morimoto T, et al
"Learning drugs reawaken grown-up brain's inner child"
Clinical trials evaluating semaglutide have not identified bone loss as a significant adverse effect, though it should be noted that bone mineral density (BMD) was not specifically assessed in most studies
If you're taking SSRIs for depression, anxiety, and related mood disorders, taking semaglutide is unlikely to significantly impact that effect
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