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This pulsatile pattern preserves the negative feedback loop: when GH and IGF-1 reach adequate levels, somatostatin signals the pituitary to pause secretion (Ishida et al., JCSM Rapid Commun, 2020)

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This creates a structural incentive to develop biologics over small molecules for certain therapeutic areas where both modalities are viable, or to invest in biologics manufacturing capabilities that support 13-year protection

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