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The physiology changes when you add training load into the equation

B.et al (1997)

It can also play a role in many immune-mediated diseases such as allergies, inflammatory bowel disease, otitis, pancreatitis, cancer and asthma

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[1] [3] Crucially for weight management, these medications act on receptors in the hypothalamus and brainstem areas that regulate appetite and satiety, leading to reduced hunger, increased feelings of fullness, and decreased food intake