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PloS one 4 , e6221, doi:10.1371/journal.pone.0006221 (2009)
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Bioactivity is often reduced by neutralizing antibodies, which can be generated at different levels, depending on the immunogenicity of the protein drug (Rossman 2004)
Coadministration of alogliptin and pioglitazone provided statistically significant improvements in A1C and FPG compared to placebo, to alogliptin alone, or to pioglitazone alone when added to background metformin therapy (Table 11, Figure 3)
Lundberg, J
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