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Khan MS, Fonarow GC, McGuire DK et al (2020) Glucagon-like peptide 1 receptor agonists and heart failure: the need for further evidence generation and practice guidelines optimization

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A 90% pure peptide behaves differently than a 98% pure peptide, and impurities in injectable-grade products carry safety implications that are not theoretical

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Any consideration of combination pharmacotherapy should involve shared decision-making, thorough discussion of risks and benefits, and close clinical follow-up