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Alcohol Consumption : Even moderate drinking depletes glutathione as your liver works to process alcohol and its toxic byproduct, acetaldehyde
Kalogerakou, T., & Antoniadou, M
Lee et al., 2020
Glutathione biosynthesis occurs in two sequential, ATP-dependent enzymatic steps that take place in the cytosol: Step 1: The enzyme glutamate-cysteine ligase (GCL) combines glutamate and cysteine to form gamma-glutamylcysteine
In the setting of SARS-CoV-2, COVID-19 and oxidative stress, patients with comorbidities may have altered levels of glutamate-cysteine ligase and GSH synthetase, the enzymes participating in GSH synthesis