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10.2337/dc13-2983 67 ThummaS.ErricoK.ManchalaV.MattanaJ
Higher yield percentages reflect minimal material loss during processing, indicating optimized resource use and greater economic return
Animal Model:Neonatal Sprague-Dawley rats (male, 18-22g, postnatal day 7), hypoxic-ischemic brain damage (HIBD) model [2] Dosage:100 mg/kg Administration:Intraperitoneal injection, once daily, for 14 consecutive days starting 24 hours after HIBD induction Result:Brain injury: Reduced infarct volume by 40% compared to the HIBD control group as measured by triphenyltetrazolium chloride (TTC) staining
Highlights: Blocks interaction between FOXO4 and p53 to induce senescent-cell apoptosis
Effectively reduce the harm of toxic substances to the human body
These findings reinforce the value of multimodal baseline profiling, integrating biochemical and retinal imaging biomarkers, to identify patients at higher risk of early disability progression and to support more personalized management strategies in MS
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