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Besides GLP-1, DPP-4 also has other substrates and their elevation by DPP-4 inhibition can also contribute to a normalization of glycaemia in type 2 diabetes (indirect target or off-target) (10)
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These findings revealed that DPP-4i, despite its additive or synergistic effects with metformin, did not present superior renoprotective effects in patients with T2DM compared with its contrasting combination groups
Gherghina, M.-E
While accidental exposure early in pregnancy does not automatically mean harm has occurred, there is not enough human safety data to recommend continued use during pregnancy
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