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There is no consistent, reproducible body of evidence [supporting increased suicidal ideation]

Largely because combining compounds with overlapping healing or anti-inflammatory reputations makes an appealing marketing story built on assumed synergy

Acta Endocrinol

Moreover, the presence of lactate transporters and pannexin-based gap junctions in astrocytes highlights their unique role in central nervous system function [12,13,14]

These markers are pathway-level

Available data indicate that SGLT2-i cause plasma renin activity (PRA) increase in the early phase of treatment, while PRA and aldosterone levels remain unchanged in chronic treated patients