While B12 has very low toxicity as a water-soluble vitamin with excess typically excreted in urine, rare adverse reactions can occur
ISO 17034:2016: General requirements for the competence of reference material producers. ISO
[14] Decourt B, DSouza GX, Shi J, Ritter A, Suazo J, Sabbagh MN
Dietary Causes Dietary causes include too much grain and not enough roughage, consumption of moldy feedstuffs, diets high in sulfur, cobalt-deficient diets, or consuming certain toxic plants such as bracken ferns
Some users report reduced appetite or changed food preferences
The insulin and glucagon concentrations of the assay wells were derived via extrapolation of ratiometric fluorescence readings (665 nm/620 nm) to a second-order quadratic polynomial curve