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Endoplasmic reticulum-mitochondrial crosstalk: a novel role for the mitochondrial peptide humanin
In diff-ARPE19 cells, a lower dose of MOTS-c can reduce the negative impact of hypoxia on cellular survival and gene expression, including apoptosis ( CASP3, CASP9 ), mitochondrial biogenesis ( TFAM, PGC-1 ), and metabolic sensor ( AMPK )