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Indeed, LOH might provide an efficient mechanism to improve the fitness of melanoma cells through the removal of multiple deleterious mutations and/or by eliminating multiple neoantigenic SNVs in single mutational events
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However, two newly developed injectable drugs, semaglutide and tirzepatide, have demonstrated remarkable weight-loss effects in multinational randomized phase III trials
The assessment is stepwise, and digital contact can work well in many cases
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