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Colonic adaptation to increased wheat fiber intake takes many months, but eventually results in increased short-chain fatty acid production and GLP-1 secretion

In response, pancreatic beta cells secrete insulin that promotes glucose absorption primarily to the liver and skeletal muscles, where it is converted to glycogen

A medication that is pharmacologically appropriate may still fail clinically if it increases reactivity

The recommended dosages are based on the data from clinical trials for that specific use. For both types, higher doses may lead to negative side effects Increasing the dosage for both types of medications can come with negative side effects (nausea, vomiting, constipation, fatigue, loss of appetite and more)

When GLP-1 medications slow gastrointestinal transit, fermentable carbohydrates remain exposed to gut microbes longer, increasing gas and bloating in susceptible individuals

To receive the maximal benefits from BPC-157 it is recommended to take for 12 weeks, with a one month break, then treatment can be restarted