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In a state of oxidative stress, the ratio can be as low as 10:1, and in severe states of oxidative stress, as low as 1:1
Cero C, Lea HJ, Zhu KY, Shamsi F, Tseng Y-H, Cypess AM
La evidencia clnica disponible es heterognea (ensayos pequeos, resultados variables), pero el mecanismo es consistente con uno de los ejes fisiopatolgicos propuestos en la enfermedad
Both work on the GLP-1 mechanism
Further research is required to establish the safety and efficacy of tesofensine as an anti-addiction medication and to determine the optimal dosing and duration of treatment