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In astrocytes, GLP-1R signaling promotes fatty acid oxidation, maintains mitochondrial integrity, and supports glucose homeostasis
(3) payload-mediated receptor engagement with potential for novel agonist pharmacology (biased signaling, sustained activation) not achievable with a small peptide
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mRNA stability and selenocysteine insertion sequence efficiency rank gastrointestinal glutathione peroxidase high in the hierarchy of selenoproteins
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