Insert the needle at a 90-degree angle in one steady motion (use 45 if you can only pinch 1 inch of skin)
treatment promoter interaction: F (10,90) = 1.1900, P = 0.3083
Reassure based on current evidence (no excess malformation risk)
This means more people can stay on tirzepatide at effective doses compared to semaglutide, which is a meaningful advantage when the goal is long-term use
As the authors stated, To our knowledge this is the first lifestyle intervention study where remission of T2D has been studied with 100% remission with a feeding study using meals and food obtained from local grocery stores. However, unlike GLP-1 drugs, a calorie-restricted diet with the same macronutrient composition as the Zone diet causes weight loss without loss of lean body mass in both individuals with type 2 diabetes (7) as well as those with pre-diabetes (8)
It reports roughly 22 percent mean body weight loss over 72 weeks for tirzepatide at the highest dose in the SURMOUNT trials, against around 15 percent for semaglutide at its highest dose in the STEP trials