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During the assessment process for major reclassifications, the MHRA may: Take advice from its expert advisory body, the Commission on Human Medicines (CHM)
We found that transferring FM IgG into mice induces pain-like behaviour, nociceptor sensitization and hyperactivity, and decreased intraepidermal nerve fiber density, which are characteristics present in some FM patients
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Conversely, severe acute oxidative stress killed GPX1/ mice, while wild-type mice supplemented with selenium survived normally
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