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Short-acting formulations reach peak plasma concentrations within 1-3.5 hours and have shorter elimination half-lives, while long-acting agents like semaglutide have half-lives of approximately one week, allowing for sustained therapeutic effects

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We further confirm that the order of authors listed in the manuscript has been approved by all of us

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The weight-loss equivalency framework (what the trials show) The table below compares mean weight loss at week 72 from the phase 3 obesity trials

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