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Two human patients with congenital leptin deficiencies were shown images of food before and after 7 days of leptin replacement therapy, and their brain responses were measured by functional magnetic resonance imaging (fMRI)
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[2] [3] They work by mimicking the action of a naturally occurring hormone called GLP-1, which is released from the intestine in response to food intake
"That alone can explain severe next-day symptoms." And for many patients, their tolerance naturally drops along with the number on the scale
