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Table 1 summarises the baseline characteristics of individuals and baseline demographics of the whole network are summarised in ESM Results

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This systematic review aimed to evaluate the potential effectiveness and safety of combination therapy of SGLT-2i and GLP-1 RA compared with monotherapy in individuals with type 2 diabetes

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L-cells function as nutrient sensors, detecting the presence of food components in the intestinal lumen and responding by secreting GLP-1 into the bloodstream

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Freezing should be avoided, as extreme temperatures can adversely affect medication stability

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Renal expression of angiotensin type 2 (AT2) receptors during kidney damage

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These pathways contribute to the regulation of food intake, glucose metabolism, and energy balance through the CNS-mediated effects of bile acids and their downstream signaling molecules

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