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Results KAT6A mutations cause a decrease in histone H3 lysine 23 (H3K23) acetylation in human cells and mice To determine the effects of mutation of the KAT6A gene on histone acetylation, we generated human HEK293T cells carrying six different KAT6A variants observed in individuals with ARTHS using CRISPR/Cas9 and homology-directed repair (Tables S1, S2, and S3)
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At a Glance The fishy odor from L-carnitine is caused by gut bacteria turning unabsorbed supplement into trimethylamine (TMA)
"For too long, we've judged, shamed, and blamed those living with obesity, treating their weight as their fault
Several clinical trials are currently underway
