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The potency of PF-06882961 (CS EC 50 = 13 nM) on the cAMP pathway was approximately 120- and 14-fold (Fig 3A, Table S2) lower than exenatide (CS EC 50 = 0.11 nM) and liraglutide (CS EC 50 = 0.95 nM), respectively
The receptors also slow down the emptying of the stomach, which prolongs the feeling of satiety after meals
The Glucagon Advantage Glucagon receptor activation, present in both compounds, may provide some protection against excessive muscle loss
Moreover, a study by Lopez and collaborators found that patients with constipation tended to have higher incidence of hypokalemia but these results didnt reach statistical significance 30
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