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Andrea Dunaif, chief of the division of endocrinology, diabetes and bone disease for the Mount Sinai Health System, tells Yahoo

A small piece of physiology gets taken out of context and then reverse engineered into a rule that sounds plausible but isnt actually supported by the mechanism

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A random-effects model was chosen because the trials differ in the populations included or in the follow-up time and because the calculated heterogeneity ( I 2 ) was elevated

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But controlled human efficacy data is sparse, and the single Phase 2 trial tested oral administration rather than the subcutaneous injection most users employ today