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The dipeptides LeuLeu and ValVal both show DPP-IV inhibitory activity, however, LeuLeuPhe and LeuVal, did not have any DPP-IV inhibitory activity ( Reference Tulipano, Sibilia and Caroli 65 )

Trojani M, Contesso G, Coindre JM, et al

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The key factors that affect Rybelsus absorption are: Taking the medication on an empty stomach Using only a small amount of plain water (no more than 120 ml) Waiting the full 30 minutes before consuming anything else For patients who experience gastro-oesophageal reflux or digestive discomfort, remaining upright after taking any medication is generally advisable as a standard precaution, but this is not a specific requirement in the Rybelsus product information

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