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Since diacylglycerol acyltransferase 1 (DGAT1) can increase the conversion of DAG into triacylglycerol (TAG), 171 DGAT1 overexpression could decrease DAG levels and improve insulin sensitivity partially attenuating the fat-induced activation of DAG-responsive PKCs

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Retatrutide is administered via subcutaneous injection using a pre-filled pen

Palamara et al., 1995, 1996