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The barrier to permeation is charge and effective hydrodynamic radius rather than raw mass, which is what the cited Hostynek and Li data actually show
Legal and Regulatory Response Lawsuits Thousands of lawsuits have been filed against Novo Nordisk and Eli Lilly, alleging that GLP-1 drugs caused: Gastroparesis (stomach paralysis) Ileus and bowel obstruction Vision loss (NAION) Gallbladder disease Psychiatric complications Death These cases are currently consolidated under MDL No
Change in body weight, waist circumference and waist-to-height ratio was assessed at 2, 3 and 4 years
We also observed no differences in the risks of GI adverse effects
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