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When this is found, consideration should be given to the possibility that any one of several rarely encountered conditions such as Peutz-Jeghers syndrome, Laugier-Hunziker syndrome, Bannayan-Riley-Ruvalcaba syndrome, LEOPARD syndrome, and the several syndromes with lentigines and cardiocutaneus myxomas may be present

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Also, be careful about giving supplements to a child, unless recommended by their healthcare provider.