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At the end of the 30 total days of treatment, patients had significant reductions in serum hepatic enzymes

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Shows that pGlu-A (especially pE3-A) accelerates oligomerization and seeding behavior compared to unmodified A Demonstrates higher neurotoxicity of pGlu-modified peptides in vitro Supports pyroglutamylation as a critical step in Alzheimers disease pathology DOI: 10.1021/bi0612667 Sewald, N., Jakubke, H.D

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Each of these scales was analyzed separately using one effect per study at the end-of-treatment time point

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