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Fig.3 Proportion of patients achieving MASH resolution without worsening of fibrosis with tirzepatide [6] While GLP-1 RAs are proving effective in treating MASH, their lack of direct action on liver tissue could limit their effectiveness in patients with advanced liver fibrosis or cirrhosis

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In absolute terms, the 12 mg dose translated to an average loss of approximately 70 pounds (32 kg) at 80 weeks of treatment

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