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Drug Safety-related Labeling Changes (SrLC)

from the mineral reign, the copper (cuprum metallicum), the Gold (aurum metallicum) and the mercury (mercurius solubillis), and finally from the vegetal, the belladonna extracted from the plant Atropa belladonna

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Second-generation inhibitors such as valspodar offered improved potency but interfered with CYP450 enzymes (e.g., CYP3A4), leading to problematic drugdrug interactions

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