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Diuretic Action of Sodium-Glucose Cotransporter 2 Inhibitors and Its Importance in the Management of Heart Failure
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Compared to hGH, AOD9604 offered similar adipose tissue effects without significantly increasing systemic growth factors, such as IGF-1
A 2006 double-blind placebo-controlled study found that a single injection of CJC-1295 DAC can [2]: Increase plasma growth hormone concentration 2-10 fold for six days Increase plasma IGF-1 concentration 1.5-4 fold for 9-12 days Based on this evidence, CJC-1295 clearly has a significant impact on GH and IGF-1 levels when administered to test subjects
In consideration of the multiple metabolic and cardiovascular effects seen in subjects treated with GLP-1RAs and SGLT-2is (e.g., reduction of hyperglycemia, weight loss, free/fat mass and bone remodeling, anti-atherosclerosis, natriuresis), it is reasonable to speculate that GH and IGF-1 may play a about a relevant role in this context
doi: 10.1155/2023/2713864 75 KimKHHongGLJungDYKarunasagaraSJeongWIJungJY
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