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Contraindications Hypersensitivity to the active substance or other components of the drug
The isoprenoid groups are attached to cysteine residues at the carboxy terminus of proteins in a thioether linkage (C-S-C)
For those with positive GPX4 expression, we categorized GPX4 + if 5% to 24% of cells were positive, GPX4 ++ if 25% to 75% of cells were positive, and GPX4 +++ if more than 75% of cells were positive after IHC staining
The primary stance of the two organizations is that, while the observed association between semaglutide and NAION of this study is interesting, more research is warranted to confirm whether the relationship is causal
Lancet Diabetes Endocrinol 6(5):361369
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