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With respect to dosage, the average reductions were: 2000 mcg: 71.5% (single data point) 1,000 mcg: 31.8% Although limited data are available for higher dosages, the findings support the efficacy of both oral and non-oral B12 formulations in modulating homocysteine levels

That said, however, in most people I usually see a noticeable (although not always lasting) improvement after 2-3 shots

Since copper is a trace mineral required in minimal doses, excess intake can cause nausea, gastrointestinal issues, and other health problems

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Its strongest route-specific evidence uses oral delivery into PepT1-rich inflamed gut tissue

Clinical Update 1/19/2024 Protein Powder Allergy