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( n ) Proportion of semaglutide responsive cells out of the total number of KCl responsive cells in elPBN SemaTRAP slices (n = 6 slices, 4 mice) or elPBN VehTRAP slices (n = 6 slices, 3 mice)

Both analyses were performed using the same methods as the primary analysis

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Dietary choline is initially metabolized by the gut microbiota into trimethylamine (TMA), which is then absorbed and further oxidized in the liver into TMAO