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8.4Metformin Metformin is primarily used for its insulin-sensitizing effects, which help address the underlying insulin resistance commonly seen in MASLD patients

GLP-1 lowers postprandial glucose excursion by potentiating glucose-stimulated insulin secretion from pancreatic -cells and has also recently been shown to promote -cell survival in rodents 2

Amyloid- deposition begins at 6 weeks of age, with microgliosis and astrocytosis, and dendritic spine loss is also observed in the mice

Reflux is causing documented esophagitis on endoscopy that is not improving

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In summary, although there are many ways to activate the c-met signaling pathway to induce the occurrence of HCC, c-met expression and activation are indispensable